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Overview: Essential thrombocythemia is a Janus kinase 2 (JAK2) mutation-prevalent myeloproliferative neoplasm characterized by clonal thrombocytosis; clinical course is often。

Thrombocythemia may lead to . Microvascular occlusions. Large vessel thrombosis . Bleeding. Microvascular occlusions involve small vessels of the distal extremities (causing。

In patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of reactive causes is particularly important ().In studies of。

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